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General Information
ZIRC
ZFIN ID: ZDB-GENE-000901-1
Gene Name: CD74 molecule, major histocompatibility complex, class II invariant chain a
Gene Symbol: cd74a    Nomenclature History

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Previous Names: Iclp-1, iclp1, MHC II (1), wu:fb11f09 (1), wu:fb12a01 (1), wu:fb13d06 (1), wu:fk94e07 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have MHC class II protein binding activity. Involved in T cell activation involved in immune response; dendritic cell antigen processing and presentation; and sensory organ development. Localizes to the cell surface. Is expressed in dendritic cell; otic vesicle; pectoral fin bud; pharyngeal arch; and sensory system. Orthologous to human CD74 (CD74 molecule).
Genome Resources: Alliance (1),  Gene:58113 (1),  Ensembl(GRCz11):ENSDARG00000009087 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-cd74a N/A 1
MO2-cd74a N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cd74a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH cd74a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process dendritic cell antigen processing and presentation (more)
Cellular Component cell surface (more)
Molecular Function MHC class II protein binding (more)
GO Terms (all 11)
TRANSCRIPTS
Type Name Length (nt) Analysis
aberrant processed transcript cd74a-202 (1)    Ensembl 534
mRNA cd74a-201 (1)    Ensembl 1273
cd74a-203 (1)    Ensembl 840
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-cd74a IgG Rabbit IHC 3
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cd74a No data available
MARKER RELATIONSHIPS
cd74a Contained in: [BAC] DKEY-201I24 (1) (order this)
cd74a Contains: [SNP] rs3728618 (1)
cd74a Encodes: [EST] fb11f09 (1), fb12a01 (1), fb13d06 (1), fk94e07 (1)
[cDNA] MGC:77643 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131590 (1) 1157 bp
Genomic GenBank:CU468924 (1) 166893 bp
Select Tool
Polypeptide UniProtKB:Q9PUT2 (1) 237 aa
Sequence Clusters UniGene:7740 (1)
Sequence Information (all 24)
ORTHOLOGY for cd74a ( Chr: 14 )
CITATIONS (38)