Gene

cd74a

ID
ZDB-GENE-000901-1
Name
CD74 molecule, major histocompatibility complex, class II invariant chain a
Symbol
cd74a Nomenclature History
Previous Names
  • Iclp-1
  • iclp1
  • MHC II (1)
  • wu:fb11f09 (1)
  • wu:fb12a01 (1)
  • wu:fb13d06 (1)
  • wu:fk94e07 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have MHC class II protein binding activity; cytokine receptor activity; and macrophage migration inhibitory factor binding activity. Involved in T cell activation involved in immune response; dendritic cell antigen processing and presentation; and sensory organ development. Localizes to cell surface. Predicted to colocalize with MHC class II protein complex. Is expressed in dendritic cell; otic vesicle; pectoral fin bud; pharyngeal arch; and sensory system. Orthologous to human CD74 (CD74 molecule).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cd74a Human Ortholog
No data available
Associated With cd74a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000716 Thyroglobulin type-1
Domain IPR015386 MHC class II-associated invariant chain/CLIP, MHC II-interacting
Family IPR043530 HLA class II histocompatibility antigen, gamma subunit
Homologous_superfamily IPR036857 Thyroglobulin type-1 superfamily
Domain Details Per Protein
Protein Length HLA class II histocompatibility antigen, gamma subunit MHC class II-associated invariant chain/CLIP, MHC II-interacting Thyroglobulin type-1 Thyroglobulin type-1 superfamily
UniProtKB:Q9PUT2 237
UniProtKB:F8W2L8 171
UniProtKB:Q9XRE4 234
UniProtKB:F8W2T5 48
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cd74a IgG Rabbit
  • IHC
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations