FIGURE

FIGURE 6

ID

ZDB-FIG-260720-13

Publication

Perone et al., 2026 - Aip mutation leads to significant alterations in gene expression, altered sensitivity to Ahr ligands, and early lethality in zebrafish

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FIGURE 6

Network of KEGG and GO:BP terms enriched via GSEA (FDR ≤0.05) using aip^−/− vs. aip^+/+ gene expression changes from five dpf RNA-seq data. The network was generated by uploading GSEA results to the Enrichment Map app within Cytoscape. Line (aip^wh86 and/or aip^wh239) is denoted by the color (light and/or dark grey) of the foreground circle of each node. Enrichment direction (over or underexpression) is denoted by the color (red or blue) of the background shape of each node. Ontology type (KEGG or GO:BP) is denoted by the background shape (square or octagon) of each node. The size of the node and node connectors (edges) is determined by the number of genes in a gene set and the number of genes shared between nodes, respectively. 25% of genes in a smaller gene set must overlap with the larger gene set to be connected with an edge. Nodes with no connections were removed and are displayed in Figure 7. The ellipses were manually curated to highlight groups of three or more similar nodes. Individual gene set names can be viewed when the image is enlarged.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aip^wh86/wh86 aip^wh239/wh239
Observed In:	amino acid metabolic process cellular response to nutrient cellular response to stress lipid metabolic process regulation of cell division regulation of response to oxidative stress xenobiotic metabolic process
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Toxicol