FIGURE

Fig. 6

ID

ZDB-FIG-260716-59

Publication

Wang et al., 2026 - Checkpoint kinase 2 coordinates autophagy activation and Aurora kinase A degradation to regulate primary cilia for cell invasion

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Fig. 6

CHEK2 maintains the primary cilia of RPE1 cells. A Depiction of experimental scheme. Fix1: serum starvation for 24 h. Fix2: serum starvation for 48 h with or without 24 CHEK2 inhibition (+/-CHEK2i). B Quantitative results of ciliated cells. Time course of quantitation of (C) ciliated cells and (D) the length of primary cilia in HTR-8 cells starved for 24 h followed by treating CHEK2 inhibitor for 0, 2, 4, 6, 8, 10, 12, 24 h. (E-F) Regrowth of primary cilia was observed after CHEK2i washout. E Schematic of the experimental protocol. Fix 1: Cells were starved for 48 h with or without CHEK2i (+/− CHEK2i). Fix 2: After treatment with CHEK2i for 48 h, the drug was washed out and the cells were cultured in drug‑free medium for an additional 24 h. F Quantification of cells with primary cilia in E. n.s.: no significance, * p < 0.05, **: p < 0.01, ***:p < 0.001. These results are mean ± SD from three independent experiments

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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