FIGURE

Fig. 7

ID

ZDB-FIG-260710-8

Publication

Tsuji et al., 2026 - Neu1 deficiency is associated with reduced nicotine responsiveness and dopamine D3 receptor downregulation in zebrafish

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Fig. 7

Effects of a D3 receptor agonist on nicotine-induced behavior in WT and neu1-KO zebrafish. WT and neu1-KO zebrafish were pretreated with the selective dopamine D3 receptor agonist PD128907 (10 µM) by waterborne exposure for 30 min prior to behavioral testing, followed by transfer to the experimental tank containing Nco (2.5 mg/L). Swimming behavior was recorded for 10 min. A Representative swimming trajectories in WT and neu1-KO zebrafish exposed to Nco alone or Nco plus PD128907. B Total swimming distance traveled during the behavioral recording period. C Swimming distance in the upper layer of the tank. D Time spent swimming in the upper layer. E Duration of excited swimming behavior. Different letters indicate statistically significant differences between the groups. n.s., not significant. n = 6

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	neu1^{zf3377/zf3377} (RW)
Conditions:	chemical treatment by environment: nicotine chemical treatment by environment: nicotine
Observed In:	behavioral response to nicotine swimming behavior
Stage:	Adult

Phenotype Detail

Acknowledgments

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