FIGURE

Figure 3

ID

ZDB-FIG-260416-52

Publication

Anderson et al., 2026 - Tissue-Specific Expression of the EWSR1::FLI1 Fusion Protein Identifies col2a1a-Positive Cells as a Source of Ewing Sarcoma-like Tumors in Zebrafish

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Figure 3

Increased DNA double-strand breaks in transgenic EWSR1::FLI1 zebrafish. γ-H2AX staining in craniofacial structures with the following: (A) Non-Tg dorsal view. (B) Non-Tg lateral view. (C) Non-Tg ventral view. (D) Tg dorsal view, with the white arrow identifying abnormal ear formation. (E) Tg lateral view. (F) Tg ventral view. These findings suggest that aberrant transcriptional activity driven by EWSR1::FLI1 induces genomic stress with R-loops and DNA double-strand breaks [22] during development, as reflected by increased γ-H2AX staining.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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