ZFIN Image: Anderson et al., 2026, Figure 3

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Figure 3

Increased DNA double-strand breaks in transgenic EWSR1::FLI1 zebrafish. γ-H2AX staining in craniofacial structures with the following: (A) Non-Tg dorsal view. (B) Non-Tg lateral view. (C) Non-Tg ventral view. (D) Tg dorsal view, with the white arrow identifying abnormal ear formation. (E) Tg lateral view. (F) Tg ventral view. These findings suggest that aberrant transcriptional activity driven by EWSR1::FLI1 induces genomic stress with R-loops and DNA double-strand breaks [22] during development, as reflected by increased γ-H2AX staining.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.