FIGURE

Fig. 4

ID

ZDB-FIG-260416-18

Publication

Qian et al., 2026 - Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5

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Fig. 4

Alterations of ferroptosis related pathways in <italic toggle='yes'>aldh3b1</italic><sup><italic toggle='yes'>-/-</italic></sup> and in 2-HD treated zebrafish.

A GO enrichment analysis of differential genes showed top altered pathways in aldh3b1^-/- compared to aldh3b1^+/+ larvae. B GO enrichment analysis of differential genes showed the top altered pathways in aldh3b1^+/+ 5dpf larvae treated with or without 2-HD. C Integrative transcriptome and metabolome analysis uncovered ferroptosis signaling alterations induced by aldh3b1 deficiency and 2-HD treatment. GO, Gene Ontology. Statistical significance for GO enrichment in Fig. 4A, B was determined using a two-sided Fisher’s exact test. P values were adjusted for multiple comparisons using the Benjamini-Hochberg method.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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