FIGURE

Fig. 4

ID

ZDB-FIG-260416-18

Publication

Qian et al., 2026 - Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Alterations of ferroptosis related pathways in aldh3b1^-/- and in 2-HD treated zebrafish.
A GO enrichment analysis of differential genes showed top altered pathways in aldh3b1^-/- compared to aldh3b1^+/+ larvae. B GO enrichment analysis of differential genes showed the top altered pathways in aldh3b1^+/+ 5dpf larvae treated with or without 2-HD. C Integrative transcriptome and metabolome analysis uncovered ferroptosis signaling alterations induced by aldh3b1 deficiency and 2-HD treatment. GO, Gene Ontology. Statistical significance for GO enrichment in Fig. 4A, B was determined using a two-sided Fisher’s exact test. P values were adjusted for multiple comparisons using the Benjamini-Hochberg method.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg/y1Tg aldh3b1^{zf4314/zf4314}
Condition:	chemical treatment by environment: 2-hexadecenal
Observed In:	cell-substrate adhesion chemical homeostasis extracellular matrix organization extracellular structure organization inorganic ion homeostasis iron ion binding iron ion transport monooxygenase activity regulation of peptidase activity tetrapyrrole binding
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.