FIGURE

Fig. 2

ID

ZDB-FIG-260416-16

Publication

Qian et al., 2026 - Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5

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Fig. 2

Microvascular alterations in <italic toggle='yes'>aldh3b1</italic><sup><italic toggle='yes'>-/-</italic></sup> mutants.

A Representative confocal images of hyaloid vasculature revealed significant vascular alterations in aldh3b1^-/- larvae at 5dpf. Yellow arrows, sprouts; yellow circles, branchpoints. White scale bar = 50 μm. B, C Quantitative analysis demonstrated a significant increase in hyaloid sprouts and branchpoints in aldh3b1^-/- larvae (n = 24/27). D Representative confocal images of adult retinal vasculature showed vascular alterations in aldh3b1^-/- zebrafish. Yellow arrows, sprouts; yellow circles, branchpoints. White scale bar = 500 μm. E, F Quantification of increased retinal sprouts and branchpoints in adult aldh3b1^-/- zebrafish. One datapoint means one 350 μm² square in high-density retina (n = 8/9). The bars indicate mean ± SD values. Statistical analysis was performed by a two-tailed Student’s t test. Source data are provided as a Source Data file.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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