IMAGE

Fig. 2

ID

ZDB-IMAGE-260416-24

Genes

EGFP

Publication

Qian et al., 2026 - Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5

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Figures for Qian et al., 2026

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Figure Caption

Fig. 2 Microvascular alterations in aldh3b1^-/- mutants.
A Representative confocal images of hyaloid vasculature revealed significant vascular alterations in aldh3b1^-/- larvae at 5dpf. Yellow arrows, sprouts; yellow circles, branchpoints. White scale bar = 50 μm. B, C Quantitative analysis demonstrated a significant increase in hyaloid sprouts and branchpoints in aldh3b1^-/- larvae (n = 24/27). D Representative confocal images of adult retinal vasculature showed vascular alterations in aldh3b1^-/- zebrafish. Yellow arrows, sprouts; yellow circles, branchpoints. White scale bar = 500 μm. E, F Quantification of increased retinal sprouts and branchpoints in adult aldh3b1^-/- zebrafish. One datapoint means one 350 μm² square in high-density retina (n = 8/9). The bars indicate mean ± SD values. Statistical analysis was performed by a two-tailed Student’s t test. Source data are provided as a Source Data file.

Figure Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.