FIGURE

Figure 3.

ID

ZDB-FIG-260413-12

Publication

Owrang et al., 2025 - Uncovering Dual Molecular Diagnoses in Families with Complex Phenotypes through Structural and Clinical Study of Novel COL4A6 Variants

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Figure 3.

Spatial and temporal expression pattern of col4a6 mRNA during zebrafish development. (A) At 1 day post-fertilization (dpf), col4a6 mRNA is expressed in the epidermis, otic vesicles (Ov), and midbrain-hindbrain boundary (MHB), where the epidermis is enlarged for clarity as shown in A″. Panel A′ shows a dorsal view of panel A with a flattened mount. (B) At 2 dpf, col4a6 mRNA is persistently expressed in the MHB, ear (enlarged in B″), and epidermis, and is beginning to be expressed in the pharyngeal arch (Pa) and pectoral fin bud (Pb). (C) At 3 dpf, col4a6 mRNA is persistently expressed in the pharyngeal arch and ear (enlarged in C′) and becomes restricted in the dorsal dermis (Dd, enlarged in C″). In addition, col4a6 mRNA is expressed in the pronephric duct (Pnd). (D) At 5 dpf, col4a6 mRNA is persistently expressed in the pharyngeal arch and ear (enlarged in D′ and dorsal view in D″), with additional expression in the intestinal bulb (IB) and cloaca (Cl). Unlabeled scale bars are 0.3 mm.

Expression Data

Gene:	col4a6
Fish:	NHGRI-1
Anatomical Terms:	cloaca dermis epidermis inner ear intestinal bulb midbrain hindbrain boundary otic vesicle pectoral fin bud pharyngeal arch pronephric duct
Stage Range:	Prim-5 to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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