FIGURE

Fig. 6

ID

ZDB-FIG-260322-42

Publication

Nelen et al., 2026 - Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors

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Fig. 6

TAS1553 induces downregulation of genes encoding splicing pathway components.

A Bubble plot showing significant downregulation of gene sets involved in RNA splicing upon treatment for 48 h with RRM2 inhibitors alone or in combination with CHK1 inhibitors in IMR-32 (left). Corresponding GSEA of two gene sets involved in RNA splicing (top) or the spliceosome (bottom) after treatment with IC₅₀ of TAS1553 in IMR-32 (right). B KEGG pathway analysis of the spliceosome in IMR-32 indicating which genes are significantly differentially expressed (blue: downregulated by TAS1553; red: upregulated by TAS1553) upon treatment with the IC₅₀ of TAS1553 for 48 h.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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