FIGURE

Fig. 2

ID

ZDB-FIG-260322-38

Publication

Nelen et al., 2026 - Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors

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Fig. 2

Benchmarking TAS1553 imposed transcriptional signatures in neuroblastoma.

A Volcano plots of IMR-32 (top) and CLB-GA (bottom) of significantly differentially expressed genes (DEGs) following TAS1553 IC₅₀ exposure for 48 h (1.18 µM and 1.54 µM respectively). Genes indicated by name cover the top 15 DEGs. NS not significant. B Bubble plots of all overlapping Hallmark MSigDB gene sets significantly up or downregulated in IMR-32 or CLB-GA cells after treatment (48 h) with their respective IC₅₀ for TAS1553 (1.18 µM and 1.54 µM) (left) or 3-AP (0.69 µM and 0.96 µM) (right). C Detailed view of the GSEA enrichment for the p53 pathway, MYC targets and G2M checkpoint Hallmark MSigDB gene sets after treatment of IMR-32 with 1.18 µM TAS1553 (IC₅₀) treatment (left) and heatmaps showing the top 50 genes within the core enrichment (right). ES enrichment score.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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