FIGURE

Fig 3

ID

ZDB-FIG-260311-715

Publication

Corcoran et al., 2026 - Combined mutations of hoxa13a, hoxa13b, and hoxd13a lead to structural shifts in zebrafish soft fin rays providing insight into spiny ray evolution

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Fig 3

Summary of defects in each fin type for triple and double homozygous hox13 mutant fish.

(A) The caudal fin demonstrates the least severe defects in these mutants. The dorsal and anal fins lack joints, bifurcations and actinotrichia, but do not have length reductions as severe as the paired fins. The paired fins demonstrate the most severe defects in hox13 double and triple homozygous mutants. (B) A summary of observed phenotypes in double and triple homozygous mutants for the presence/ absence of joints, bifurcations and actinotrichia, as well as severity of length reductions. The genotypes of the double and triple mutants are indicated in the left column: Heterozygotes for each gene are shown in green, homozygous mutants are shown in red, and wildtypes are shown in black. Number of fish observed for each group include n = 6 for wildtype siblings, n = 8 for hoxa13a^-/-, a13b^-/-, d13a^-/+, and n = 10 for hoxa13a^-/-, a13b^-/-, d13a^-/-, n = 11 for hoxa13a^-/-, a13b^-/+, d13a^-/-, n = 9 for hoxa13a^-/+, a13b^-/-, d13a^-/-, n = 2 for hoxa13a^-/-, a13b^-/-, d13a^+/+. Bright field image examples for each mutant are shown in Fig 4.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hoxa13a^{ot1013/ot1013}; hoxa13b^{ot1014/ot1014}; hoxd13a^ot1015/+ hoxa13a^{ot1013/ot1013}; hoxa13b^{ot1014/ot1014}; hoxd13a^{ot1015/ot1015}
Observed In:	anal fin joint anal fin lepidotrichium branched anal fin ray branched caudal fin ray branched caudal fin ray actinotrichium branched dorsal fin ray branched dorsal fin ray actinotrichium dorsal fin joint dorsal fin lepidotrichium pectoral fin joint pectoral fin lepidotrichium pelvic fin joint pelvic fin lepidotrichium
Stage:	Adult

Phenotype Detail

Acknowledgments

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