FIGURE

Fig. 7

ID

ZDB-FIG-260210-172

Publication

Gao et al., 2026 - Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Zebrafish larvae deficient for Vps18 recapitulate the patient’s phenotype.

A, B Exemplary maximum intensity projections (A) and total neutrophil counts (B) of vps18^+/+ and vps18^+/- mutant 1 and 2 zebrafish larvae at 3 dpf. Endothelial cells, green. Neutrophils, red. Scale bars, 200 μm. Mean ± SEM of ≥ 36 individual larvae of ≥7 independent experiments. ***P < 0.001, ****P < 0.0001. Unpaired t test.

Expression Data

Genes:	DsRed2 EGFP
Fish:	vps18^mde403/+; nz50Tg/nz50Tg; y1Tg/y1Tg vps18^mde404/+; nz50Tg/nz50Tg; y1Tg/y1Tg
Anatomical Terms:	neutrophil vasculature
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	vps18^mde403/+; nz50Tg/nz50Tg; y1Tg/y1Tg vps18^mde404/+; nz50Tg/nz50Tg; y1Tg/y1Tg
Observed In:	neutrophil neutrophil apoptotic process neutrophil differentiation
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Death Dis.