FIGURE

Fig. 2

ID

ZDB-FIG-260203-9

Publication

Herget et al., 2025 - Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons

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Fig. 2

Optogenetic stimulation of QRFP neurons suppresses locomotor activity and increases sleep Fish in which qrfp-expressing neurons are optogenetically stimulated (red) show a decrease in locomotor activity (A and C) and an increase in sleep (B and D) compared with non-transgenic sibling controls (blue) both at night (A and B) and during the day (C and D). Gray and blue shading indicate darkness and blue light exposure, respectively. Values during blue light exposure are normalized to values during the 30 min prior to blue light exposure. Blue light onset induces a brief startle response, which is excluded from the analysis. Mean ± SEM line plots and Tukey boxplots are shown. n = number of fish. ∗∗p < 0.01, ∗∗∗∗p < 0.0001 by Mann-Whitney U test. See also Figures S1 and S2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ct878Tg/+ ct878Tg/ct878Tg
Condition:	lighting conditions
Observed In:	locomotory behavior sleep homeostasis
Stage:	Day 4

Phenotype Detail

Acknowledgments

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