FIGURE

Figure 6

ID

ZDB-FIG-260124-6

Publication

Gil et al., 2025 - A Zebrafish Seizure Model of cblX Syndrome Reveals a Dose-Dependent Response to mTor Inhibition

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Figure 6

High dose inhibition of mTor increases the small distance and small duration in the hcfc1a^co60/+ allele. Zebrafish larvae were treated with 350 nM torin1 and exposed to 1 µM PTZ (seizure-inducing). Eight parameters were analyzed for each group: small count (A), small duration (B), small distance (C), large count (D), large duration (E), large distance (F), total distance (G), and speed (H). * p < 0.05. Numbers of animals per group are as follows: sib veh PTZ neg N = 20, sib Veh PTZ Pos N = 20, hcfc1a^co60/+ PTZ Pos N = 28, and hcfc1a^co60/+ torin1 PTZ Pos N = 30.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hcfc1a^co60/+ (AB/TL)
Conditions:	chemical treatment by environment: torin 1 chemical treatment by environment: pentetrazol
Observed In:	swimming behavior
Stage:	Day 5

Phenotype Detail

Acknowledgments

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