FIGURE

Fig. 2.

ID

ZDB-FIG-251230-85

Publication

Mensching et al., 2025 - Cohesin protein Smc3 influences kinocilial structure and function

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Fig. 2.

Smc3 KD results in decreased hair cell number in neuromasts along the lateral line. (A) 3D maximum projection representative images of SC-KD (left) and Smc3-KD (right) MI1 neuromasts observed. Hair cells are visualized with an HCS-1 antibody at a 1:100 dilution to label Otoferlin. Scale bar: 8.4 µm in the x and y dimensions. (B) Quantification of the decrease in observed hair cells per neuromast in 5 dpf Smc3-KD larvae as compared to SC-KD. Student's t-test, P<0.0001. Five neuromasts were observed per embryo n=15, Smc3-KD embryo n=23.

Expression Data

Antibody:	Ab1-otof
Fish:	C32 C32 + MO4-smc3
Knockdown Reagent:	MO4-smc3
Anatomical Term:	neuromast hair cell
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	C32 + MO4-smc3
Knockdown Reagent:	MO4-smc3
Observed In:	neuromast hair cell
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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