FIGURE

Figure 2.

ID

ZDB-FIG-251219-49

Publication

Stonkus et al., 2025 - A new role for PHYHD1 and related dioxygenases: demethylation of 2'-O-methylated nucleosides

Other Figures

All Figure Page

Back to All Figure Page

Figure 2.

Evolutionary analysis of representative phytanoyl-CoA dioxygenase (PHYH), PHYH domain-containing 1 (PHYHD1), and other related protein sequences. Dioxygenases marked in red exhibited in vitro 2′-O-methyl nucleoside demethylation activity when tested with 2′-O-methyluridine, 2′-O-methylcytidine, 2′-O-methyladenosine, and 2′-O-methylguanosine. The enzyme shown in purple displayed activity exclusively toward 2′-O-methylguanosine in vitro, whereas those marked in blue were tested but showed no detectable demethylation activity.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nucleic Acids Res.