ZFIN Image: Stonkus et al., 2025, Figure 2.

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Figure Caption

Figure 2.

Evolutionary analysis of representative phytanoyl-CoA dioxygenase (PHYH), PHYH domain-containing 1 (PHYHD1), and other related protein sequences. Dioxygenases marked in red exhibited in vitro 2′-O-methyl nucleoside demethylation activity when tested with 2′-O-methyluridine, 2′-O-methylcytidine, 2′-O-methyladenosine, and 2′-O-methylguanosine. The enzyme shown in purple displayed activity exclusively toward 2′-O-methylguanosine in vitro, whereas those marked in blue were tested but showed no detectable demethylation activity.

Acknowledgments

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