Fig. 6

Sfrp1a is required for proper HSPC development and differentiation. A. Table summarizing the role of Sfrp1a in HSPC development. Magenta arrow heads indicate an increase while the blue arrow heads indicate a decrease. NC indicates no change. B. Schematic of where Sfrp1a may regulate differentiation into lymphoid and myeloid lineages. C. Prior to 20 hpf, Wnt proteins are expressed and secreted from the somites where they encounter Sfrp1a proteins secreted from endothelial cells. Sfrp1a may modulate Wnt signaling by influencing the interaction between Wnts and Fzd receptors on the surface of endothelial cells, thereby regulating HSPC development. NT, neural tube; NC, notochord. D. Alteration frequency of SFRP1 variants in human hematopoietic malignancies (de Bruijn et al., 2023; Gao et al., 2013; Cerami et al., 2012).