FIGURE

Fig. 4

ID

ZDB-FIG-251129-106

Publication

Dougnon et al., 2025 - Behavioral and molecular insights into anxiety in ube3a and fmr1 zebrafish models of autism spectrum disorders

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Locomotor and anxiety-related behavior during the LDT and novel tank test (NTT) in adult ube3a and fmr1 zebrafish.

(A) Distance travelled, average speed, percentage of time spent in the light and exploration of the lit zone by ube3a WT (N = 15) and mutant (N = 15) adult zebrafish. (B) Distance travelled, average speed, percentage of time spent in the light and exploration of the lit zone by fmr1 WT (N = 14) and mutant (N = 17) adult zebrafish. (C) Distance travelled, number of entries in the top half, latency to first enter and proportion of time spent in the top half of the tank by ube3a WT (N = 12) and mutant (N = 11) adult zebrafish. (D) Distance travelled, number of entries in the top half, latency to first enter and proportion of time spent in the top half of the tank by fmr1 WT (N = 13) and mutant (N = 12) adult zebrafish. Unpaired t tests (A – D). The data are presented as violin plots with individual values. Exact P values are presented in the Figures. Zebrafish drawings were created using BioRender.com.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fmr1^nii8/nii8 (AB) ube3a^{sa9479/sa9479} (AB)
Condition:	altered light dark cycle
Observed In:	locomotory exploration behavior swimming behavior
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Transl Psychiatry