FIGURE

Fig. 2

ID

ZDB-FIG-251129-104

Publication

Dougnon et al., 2025 - Behavioral and molecular insights into anxiety in ube3a and fmr1 zebrafish models of autism spectrum disorders

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Locomotor activity during the light-dark test (LDT) in larval ube3a and fmr1 zebrafish.

(A) Representative movement traces of ube3a WT and mutant larvae during alternating light and dark phases (Left panel); Mean distance travelled across all light and dark phases in ube3a WT and mutant larvae by 10-s time bins (Middle panel); Distance travelled (mm) and velocity (mm/s) between WT (N = 12) and mutants (N = 11); unpaired t test. (B) Representative movement traces of fmr1 WT and mutant larvae during alternating light and dark phases (Left panel); Mean distance travelled across all light and dark phases in fmr1 WT and mutant larvae by 10-s time bins (Middle panel); Distance travelled (mm) and velocity (mm/s) between WT (N = 12) and mutants (N = 12); unpaired t test. (C) Genotype: stimulus effect calculated as the dark-light effect per larvae in each genotype; unpaired t tests. The data are presented as boxplots with whiskers (IQR-based). Exact P values are provided in the Figures.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fmr1^nii8/nii8 (AB) ube3a^{sa9479/sa9479} (AB)
Condition:	altered light dark cycle
Observed In:	swimming behavior
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Transl Psychiatry