FIGURE

Fig. 6

ID

ZDB-FIG-250909-23

Publication

Wang et al., 2025 - Lacosamide Is a Novel Drug That Improves AGTPBP1 Knockout-Mediated Impairment of Neuronal and Dopaminergic Function

Other Figures

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Fig. 6

LCM restores brain size in AGTPBP1 MO-injected zebrafish embryos. A Confocal imaging of embryonic zebrafish brain at 72 hpf. Kaede was shown in green. White dotted line: forebrain; red: midbrain; and yellow: cerebellum. B Quantification of brain volume, including the forebrain, midbrain, and cerebellum before and after LCM treatment. Forebrain size of WT and MO-injected embryos (n = 3, p < 0.0001); forebrain size of MO-injected embryos with and without LCM treatment (n = 3, p = 0.0003); midbrain size of WT and MO-injected embryos (n = 3, p < 0.0001); midbrain size of MO-injected embryos with and without LCM treatment (n = 3, p = 0.0442); cerebellum size of WT and MO-injected embryos (n = 3, p = 0.0061); cerebellum size of MO-injected embryos with and without LCM treatment (n = 3, p = 0.0214). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Data were analyzed by one-way ANOVA, followed Tukey’s test. Data were presented as mean ± SEM

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rw0130aTg + MO1-agtpbp1 (AB)
Condition:	chemical treatment by injection: lacosamide
Knockdown Reagent:	MO1-agtpbp1
Observed In:	cerebellum forebrain midbrain
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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