FIGURE

Fig. 5

ID

ZDB-FIG-250909-22

Publication

Wang et al., 2025 - Lacosamide Is a Novel Drug That Improves AGTPBP1 Knockout-Mediated Impairment of Neuronal and Dopaminergic Function

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Fig. 5

Dopaminergic state in AGTPBP1 KO cells. A Western blot of TH, DDC, D1DR, D2DR, and DAPRR32 of D7 WT and D7 AGTPBP1 KO cells with vehicle or LCM treatment; B quantification of TH, DDC, D1DR, D2DR, and DAPRR32 levels. There was significant difference in the expression levels of TH, DDC, D1DR, D2DR, and DAPRR32 between WT and AGTPBP1 KO cells. LCM treatment led to significantly reduced expression of D1DR, D2DR, and DARPP-32. Although there was also reduced expressions of TH and DDC, they were not statistically significant; C HPLC of HVA in the extracellular medium. There was a significant increase of HVA concentration in AGTPBP1 KO group. LCM treatment led to significantly reduced concentration of HVA in AGTPBP1 KO group. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Data were analyzed by two-way ANOVA, followed by Tukey’s test. Data were presented as mean ± SD

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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