FIGURE

Fig. 1

ID

ZDB-FIG-250909-18

Publication

Wang et al., 2025 - Lacosamide Is a Novel Drug That Improves AGTPBP1 Knockout-Mediated Impairment of Neuronal and Dopaminergic Function

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Fig. 1

Loss of AGTPBP1 decreases MTT absorbance value and disturbs mitochondrial functions. A Western blotting of AGTPBP1 protein in WT and AGTPBP1 KO cells (proliferation day 7). B MTT assay on undifferentiated WT and AGTPBP1 KO cells after 7-day growth, expressed as ratios of WT cells (n = 5, p = 0.0039). C MTT assay on differentiated WT and AGTPBP1 KO cells after 7 days of differentiation (n = 5, p = 0.029). D Hoechst staining assay for cell death counting of differentiated WT and AGTPBP1 cell at differentiation D7. E ROS production in WT and AGTPBP1 KO cells at differentiation D7 (n = 18, p = < 0.0001); and F JC-1 stain of differentiated WT and AGTPBP1 KO cells after 7 days of differentiation. JC-1 ratio green/red of WT and AGTPBP1 KO cells were collected. Data were compared with the values of WT *100% (n = 17, p = 0.0047). *p < 0.05, **p < 0.01, ****p < 0.0001; ns, no significance. Data were analyzed by unpaired t-test. Data were shown as mean ± SD

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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