FIGURE

Fig 7

ID

ZDB-FIG-250904-38

Publication

Farr et al., 2025 - A systems genetics approach identifies roles for proteasome factors in heart development and congenital heart defects

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Fig 7

Cardiac function deficits are observed by 4 dpf in pomp and psmd6 mutants.

A.-F. Brightfield views of hearts taken from videos of 3 dpf and 4 dpf larvae. A’-F’ panels show ventricles outlined in red. Arrowheads in E’ and F’ point to edema. Scale bars = 100 μm. G.-I. Graphs showing ventricular area, heart rate, and ventricular fractional area change (FAC) measurements at 3 dpf. Each dot represents the average of 3 measurements from a single heart/larva. Bars represent mean +/- SEM. Animals were genotyped after video recordings. N = 13 for pomp control (+/+). N = 7 for psmd6 control (+/+). N = 7 for pomp^-/-. N = 8 for psmd6^-/-. * P < 0.05. J.-L. Graphs showing ventricular area, heart rate, and ventricular FAC measurements at 4 dpf. Each dot represents the average of 3 measurements from a single heart/larva. Bars represent mean +/- SEM. Animals were genotyped after video recordings. N = 12 for all conditions: pomp control (+/+ and +/-), psmd6 control (+/+ and +/-), pomp^-/-, and psmd6^-/-. ** P < 0.01; **** P < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pomp^scm41/scm41; twu34Tg psmd6^scm40/scm40; twu34Tg
Observed In:	heart heart contraction pericardium
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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