FIGURE

Fig 6

ID

ZDB-FIG-250904-37

Publication

Farr et al., 2025 - A systems genetics approach identifies roles for proteasome factors in heart development and congenital heart defects

Other Figures

All Figure Page

Back to All Figure Page

Fig 6

pomp and psmd6 mutants exhibit myocardial cell blebbing.

A.-C. Ventral views of hearts as maximum intensity projections (MIPs) of the entire myocardium, labeled with myl7:EGFP in 4 dpf larvae. Scale bar = 100 μm. V, ventricle. A, atrium. D.-F. Ventral views of hearts as MIPs of 2-7 slices (1.6-5.6 μm total section thickness) through the ventral ventricular wall, labeled with myl7:EGFP in 4 dpf larvae. Arrows in E and F indicate examples of rounded cardiomyocytes in the interior wall of the ventricle. Hearts in D - F are from different larvae than those in A - C. Presence of rounded trabecular cardiomyocytes: 0/17 pomp⁺^/⁺, 1/15 psmd6⁺^/⁺, 25/29 pomp^-/-, 24/27 psmd6^-/-. All embryos were genotyped. Scale bar = 50 μm. G. Graph showing numbers of protruding rounded cardiomyocytes per heart at 4 dpf. Only cells clearly projecting outward from the surface of the heart were counted. Each dot represents a heart/larva. Bars represent mean +/- SD. N = 9-13 per genotype. **** P < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pomp^scm41/scm41; twu34Tg psmd6^scm40/scm40; twu34Tg
Observed In:	heart trabecular layer cardiac muscle cell
Stage:	Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.