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Fig 7

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Publication: Farr et al., 2025 - A systems genetics approach identifies roles for proteasome factors in heart development and congenital heart defects
All Figures: Figures for Farr et al., 2025

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Fig 7 Cardiac function deficits are observed by 4 dpf in pomp and psmd6 mutants.

A.-F. Brightfield views of hearts taken from videos of 3 dpf and 4 dpf larvae. A’-F’ panels show ventricles outlined in red. Arrowheads in E’ and F’ point to edema. Scale bars = 100 μm. G.-I. Graphs showing ventricular area, heart rate, and ventricular fractional area change (FAC) measurements at 3 dpf. Each dot represents the average of 3 measurements from a single heart/larva. Bars represent mean +/- SEM. Animals were genotyped after video recordings. N = 13 for pomp control (+/+). N = 7 for psmd6 control (+/+). N = 7 for pomp^-/-. N = 8 for psmd6^-/-. * P < 0.05. J.-L. Graphs showing ventricular area, heart rate, and ventricular FAC measurements at 4 dpf. Each dot represents the average of 3 measurements from a single heart/larva. Bars represent mean +/- SEM. Animals were genotyped after video recordings. N = 12 for all conditions: pomp control (+/+ and +/-), psmd6 control (+/+ and +/-), pomp^-/-, and psmd6^-/-. ** P < 0.01; **** P < 0.0001.

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