Identifying new candidate CHD genes. A. Correlation of high shet genes with genes exhibiting damaging de novo variants in CHD cases (black bars; P = 1.09E-19). No correlation is observed between shet deciles and damaging de novo variants observed in controls (grey bars; P = 0.7). shet deciles are from Cassa et al.’s Supplementary Table 1 [23]. de novo variant data are from Jin et al.’s Supplementary Data Set 9 (CHD cases) and Supplementary Data Set 10 (controls) [18]. B. Correlation of high shet genes with known CHD genes, defined by [22] (S1 Table). shet deciles are from [23]. C. Venn diagram showing overlap of genes with high shet values in pink (3190 genes; S2 Table; top 2 deciles in dataset from [23]) and genes expressed in the mouse cardiac muscle cell lineage in green (1119 genes; S3 Table; datasets from [33] and [34]). The intersection is 245 candidate genes for CHDs (S4 Table). D. Venn diagram showing overlap of our Candidate CHD gene set in maroon (245 genes; S4 Table) and known CHD genes in purple (132 genes; S1 Table; [22]). The intersection is 11 genes, shown in the box. E. Gene Ontology (GO) term enrichment for candidate gene set, obtained using DAVID. The number of genes (out of 245) represented by each term is shown on top of each bar. Bonferroni-adjusted P values are shown.
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