FIGURE

Fig. 3

ID

ZDB-FIG-250903-57

Publication

Wu et al., 2025 - Ace2 mutation disrupts amino acid absorption, impairs growth, and alters microbiota dynamics in zebrafish

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Fig. 3

Disruption of Ace2 in zebrafish significantly decreased intestinal microbial diversity and altered intestinal community composition. a Bacterial OTU numbers in the ace2 homozygous mutants and sibling heterozygous controls at 110 dpf, respectively (n = 6/each group). b Difference in the gut bacterial α-diversity of zebrafish between the ace2 homozygous mutants and sibling heterozygous controls at 110 dpf (n = 6/each group). c Non-metric multidimensional scaling (NMDS) and d analysis of similarity (Anosim) results showed that there were significantly (P = 0.001) differences in gut community structure between the ace2 homozygous mutants and sibling heterozygous controls at 110 dpf (n = 6/each group). e Differences in the bacterial community composition within zebrafish gut between the ace2 homozygous mutants and sibling heterozygous controls at 110 dpf (n = 6/each group). f LEfSe results of bacterial indicator species in guts of the ace2 homozygous mutants and sibling heterozygous controls at 110 dpf (n = 6/each group).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ace2^{syu701/syu701}
Observed In:	intestine host-mediated modulation of intestinal microbiota composition
Stage:	Adult

Phenotype Detail

Acknowledgments

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