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Fig. 3 Disruption of Ace2 in zebrafish significantly decreased intestinal microbial diversity and altered intestinal community composition. a Bacterial OTU numbers in the ace2 homozygous mutants and sibling heterozygous controls at 110 dpf, respectively (n = 6/each group). b Difference in the gut bacterial α-diversity of zebrafish between the ace2 homozygous mutants and sibling heterozygous controls at 110 dpf (n = 6/each group). c Non-metric multidimensional scaling (NMDS) and d analysis of similarity (Anosim) results showed that there were significantly (P = 0.001) differences in gut community structure between the ace2 homozygous mutants and sibling heterozygous controls at 110 dpf (n = 6/each group). e Differences in the bacterial community composition within zebrafish gut between the ace2 homozygous mutants and sibling heterozygous controls at 110 dpf (n = 6/each group). f LEfSe results of bacterial indicator species in guts of the ace2 homozygous mutants and sibling heterozygous controls at 110 dpf (n = 6/each group).