FIGURE

Fig. 4

ID

ZDB-FIG-250901-31

Publication

Malarz et al., 2025 - Unveiling the role of Ndrg1 gene on the oxidative stress induction behind the anticancer potential of styrylquinazoline derivatives

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

The impact of IS20 on the expression of selected genes and proteins associated with oxidative stress and iron regulation in the K562 (A) and U-251 cells (B,C). The HO-1 expression was determined in kinetic experiments, while Ndrg1, calreticulin, and IDH-1 gene expression after 24-hour incubation. The levels of HO-1 and HIF-1α proteins were determined after 24-h treatment with IS20 in U-251 cells. The results of gene and protein expression are presented as the mean ± SD of several independent experiments (n = 5). Immunoblots shown are representative of five independent experiments. The displayed blots were cropped, and the full-length blots are shown in Fig. S6. The statistical analysis was performed using a t-test or one-way ANOVA with Bonferroni’s posthoc test: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 compared to the untreated controls.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.