FIGURE

Fig. 2

ID

ZDB-FIG-250813-7

Publication

Babu et al., 2025 - Specific oncogene activation of the cell of origin in mucosal melanoma

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Fig. 2

Zebrafish MM has a distinct cellular state from CM. Volcano plots derived from DESeq2 of A bulk RNA-seq from zebrafish MM (n = 5) vs. CM (n = 3) and B ATAC-seq from zebrafish MM (n = 3) vs. CM (n = 3). C IGV plot of ATAC-seq showing chromatin accessibility at tfap2a and tfap2b in zebrafish MM vs. CM. Boxes = loci used for tfap2b reporter. D, E tfap2b enhancer driving GFP preferentially labels internal mitfa-mCherry labeled melanocytes in 6-day old Casper zebrafish. n = 6 zebrafish. D Fluorescent images. Scale bar = 500 μm. E Reporter expression quantification. *** = 0.0003, 2-way ANOVA with multiple comparisons. Mean ± SD. Source data are provided in Source Data Fig. 2E.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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