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Fig. 3

ID

ZDB-FIG-250728-133

Publication

Jiang et al., 2025 - Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA

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Fig. 3

Lactobacillus reuteri E9 suppresses PTZ-induced neuronal hyperactivity in zebrafish brains. Zebrafish in (A) normal (control group), (B) PTZ-induced model (model group), (C) GABA-treated (positive group), and E9-ttreated with different concentrations (expriment groups): (D) 1 × 104 CFU/mL, (E) 1 × 105 CFU/mL and (F) 1 × 106 CFU/mL. The left part show fluorescence images of brain activity in Tg(Elavl3:H2B-GCaMP6f) zebrafish (blue: baseline activity; yellow: PTZ-induced hyperactivity). The right part present quantification of brain discharge area (normalized to control). Data are mean ± SEM (n = 8 per group). E9 treatment (1% v/v, 7 days) significantly reduced PTZ-induced neuronal excitation. Imaging parameters: 20 × objective, 488 nm excitation.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Biosci (Landmark Ed)