FIGURE

Fig. 6

ID

ZDB-FIG-250722-57

Publication

Fehilly et al., 2025 - Germline Disruption of Retinal Pigment Epithelium-Expressed Zebrafish rlbp1b^-/- Results in Selective Dim Light Visual Behavior Deficits and Provides a Screening Platform for Evaluating the Pathogenicity of Human RLBP1 Variants

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Fig. 6

Proteomic profile of rlbp1b knockout zebrafish eyes shows defects in proteins related to vitamin A metabolism, ferroptosis, and lipid metabolism/storage. (A) Summary statistics of differentially expressed proteins identified in this experiment. (B) Heatmap showing clustering of differentially expressed proteins in wildtype and rlbp1b knockout zebrafish eyes. (C) Volcano plot showing differentially expressed upregulated and downregulated proteins in rlbp1b knockout zebrafish eyes. (D) DAVID gene ontology enrichment analysis showing enriched ‘Biological Process’ terms in this dataset. (E) DAVID gene ontology enrichment analysis showing enriched ‘Molecular function’ terms in this dataset. (F) Selected vitamin A metabolism proteins that are differentially expressed (Red—upregulated, Blue—downregulated) in the rlbp1b knockout or not statistically different in the rlbp1b knockout. (G) KEGG pathway for Retinol metabolism with differentially expressed proteins highlighted. (H) Differentially expressed Ferroptosis proteins in this dataset. (I) KEGG pathway for Ferroptosis with differentially expressed genes highlighted. (J) Differentially expressed Lipid metabolism and storage genes in this dataset.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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