FIGURE

Fig. 6

ID

ZDB-FIG-250716-92

Publication

Sewgoolam et al., 2025 - Genome-wide antibiotic-CRISPRi profiling identifies LiaR activation as a strategy to resensitize fluoroquinolone-resistant Streptococcus pneumoniae

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

A combination of bacitracin together with ciprofloxacin or levofloxacin increases the potency of these fluoroquinolones.

A Ciprofloxacin (5 mg/ml) disc diffusion assays show an increased zone-of-inhibition of strain D39V with the addition of 0.5 μg/ml bacitracin (BAC). Checkerboard assays with levofloxacin (LEV) and BAC indicate a synergistic interaction (FICI = 0.5) for (B) D39V and the fluoroquinolone-resistant strains (C) FQR_25191 and D FQR_40109 (see Methods).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.