FIGURE

Fig. 6

ID

ZDB-FIG-250526-52

Publication

Kim et al., 2025 - Cohesin organizes 3D DNA contacts surrounding active enhancers in C. elegans

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Fig. 6

Fountains are heterogeneous. (A) Hi-C snapshot of a locus containing broadly distributed PQN-85 around fountain origins forming a TAD-like pattern. The trajectory cartoon shows one possible interpretation in which broadly loaded cohesins form multilayered nested loops (blue, green, purple), giving rise to a broad region of enriched contact. (B) Hi-C snapshot of a locus containing two nearby fountains forming “stripes.” The trajectory cartoon shows one possible interpretation, in which collision of two-sided loop-extruding cohesins from two fountain origins stall each other, causing them to behave as one-sided loop-extruding factors (red). The collision results in nested loops, in which the outer loop (blue) forms enriched contact away from the main diagonal.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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