FIGURE

Fig. 8

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ZDB-FIG-250521-19

Publication

Ford et al., 2025 - Nkx2.7 is a conserved regulator of craniofacial development

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Fig. 8

Nkx2.7 is required for dorsal-ventral patterning of PA domains. A–F ISH for edn1 and barx1 at 26 hpf demonstrates decreased expression of each respective ventral gene in PA1 of nkx2.7−/− (n = 17 and 13, respectively) compared to wild-type (n = 26 and 22, respectively) and nkx2.5−/− (n = 11 and 11, respectively) embryos. Black arrows point to significantly diminished expression of each gene in PA1. Dorsal views, anterior to the top. Scale bar, 50 μm. G–I nkx3.2 is expressed in the first arch mesenchyme and pharyngeal endoderm in wild-type (n = 34) and nkx2.5−/− (n = 24) embryos at 52 hpf. However, its expression is eradicated in the pharyngeal arches of nkx2.7−/− embryos (n = 20). Black arrow points to significantly diminished expression in PA1. Lateral views, anterior to the left. Scale bar, 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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