FIGURE

Fig. 3.

ID

ZDB-FIG-250515-48

Publication

Zheng et al., 2025 - Modeling ANKRD26 5'-UTR mutation-related thrombocytopenia in zebrafish

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Fig. 3.

Thrombocyte counts and their adhesion/aggregation on a collagen surface under flow. (A-C) Total (A), young (B) and mature (C) thrombocyte counts in wt (n=12), ankrd26^ku6/+ (n=15) and ankrd26^ku6 (n=12) zebrafish. The data shown represent the individual values, mean and s.e.m. Kruskal–Wallis analysis was used to determine statistical significance. (D) The surface coverage of fluorescent thrombocytes on a fibrillar collagen-coated surface in the microfluidic channel after perfusion of pooled whole blood obtained from wt (top) and ankrd26^ku6 (bottom) zebrafish under arterial shear (15 dyne/cm²). (E) The rate of fluorescence accumulation (or thrombocyte adhesion) on a fibrillar collagen-coated surface following perfusion of pooled whole blood from wt and ankrd26^ku6 zebrafish. Data are presented as the mean±s.e.m. from three independent experiments. ns, P>0.05; *P<0.05 and ***P<0.005.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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