FIGURE
Fig. 3
- ID
- ZDB-FIG-250425-13
- Publication
- Huang et al., 2025 - Identification and functional validation of a novel FBN1 variant in a Marfan syndrome family using a zebrafish model
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Fig. 3
Structure analyses of the nonsense mutation in the calcium binding (cb) epidermal growth factor (EGF)-like31 domain. (A-B) Generation of fbn1+/− zebrafish. The conserved domains of FBN1 protein in zebrafish are shown. The red box indicates the locus of the nonsense mutation, and the red highlight indicates the target of CRISPR/Cas9 gene editing. WT: wildtype. (C) Sequencing chromatograms of wild type and the mutant allele. The CRISPR/Cas9 induced the mutation containing a terminator insertion in fbn1 |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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