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Fig. 3 Structure analyses of the nonsense mutation in the calcium binding (cb) epidermal growth factor (EGF)-like31 domain. (A-B) Generation of fbn1+/− zebrafish. The conserved domains of FBN1 protein in zebrafish are shown. The red box indicates the locus of the nonsense mutation, and the red highlight indicates the target of CRISPR/Cas9 gene editing. WT: wildtype. (C) Sequencing chromatograms of wild type and the mutant allele. The CRISPR/Cas9 induced the mutation containing a terminator insertion in fbn1
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Full text @ BMC Genomics