FIGURE

Fig. 5

ID

ZDB-FIG-250424-37

Publication

Scerbo et al., 2025 - In vivo targeted and deterministic single-cell malignant transformation

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Fig. 5

A two-step ?Vogelgram? model of deterministic and irreversible single-cell malignant transformation in vivo. Within a healthy tissue, a normal cell (in light gray) acquires (step 1) genetic mutation(s) in driver oncogene(s) (Mut-Drivers such as kRASG12V). Such a mutant cell (in blue, referred to as a preprocancer [Brash, 2015] cell) can (step 2) aberrantly activate the expression of Epi-Drivers involved in pluripotency/reprogramming (e.g. VENTX/NANOG, POU5/OCT4) thus undergoing deterministic and irreversible malignant cell transformation (red cell, the cell of origin of cancer); (step 3) in situ short-range dispersal of the early malignant cells and (step 4) further progression to cancer mass and to the appearance of metastatic cells. Inversely, the mutant (preprocancer) cell (in blue) can maintain its physiological functions and be eventually eliminated from the healthy tissue.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

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