FIGURE

Fig. 4

ID

ZDB-FIG-250421-76

Publication

Huybrechts et al., 2025 - Loss of the Ubiquitin-Associated Domain of sqstm1/p62 in Zebrafish Causes a Phenotype Resembling Paget's Disease of Bone

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Fig. 4

Quantitative µCT analysis using FishCuT of sqstm1tmΔUBA zebrafish at 12 mpf. a Heatmaps representing the specific FishCuT parameters for 3 individual animals per group. The standard score represents the difference between a value of a parameter in each vertebral body and the mean value of that parameter across all vertebrae in the wild-type population, divided by the standard deviation across all vertebrae in wild-type zebrafish. b Schematic overview of the different FishCuT parameters measured in the vertebral column of each vertebral body. c Quantification of the vertebral centrum length in sqstm1+/+ and sqstm1tmΔUBA/+ animals at 12 mpf (n = 9/genotype) d Quantification of the TMD at the neural arches and spines, e hemal arches and spines, and f centrum of the same zebrafish. g Quantification of the thickness of the neural arches/spines, h the hemal arches/spines, and i the centrum of the different vertebral bodies of the same zebrafish. Data are shown as mean ± SEM and statistical analysis was performed using the global test with p ≤ 0.05 considered significant. TMD, tissue mineral density

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sqstm1^zf4282/+ (AB)
Observed In:	centrum hemal arch neural arch neural spine
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Calcif. Tissue Int.