FIGURE

Fig. 2

ID

ZDB-FIG-250421-122

Publication

Xiao et al., 2025 - Deficiency of psmb6 suppresses proteasome activity and promotes apoptosis in larval zebrafish brain

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Fig. 2

The psmb6 mutants have midcranial nerve injury. (A) Timelapse confocal images of Tg(elavl3:EGFP) were taken to observe the neuron development in psmb6 mutants. Scale bars: 50 μm. (B) Timelapse confocal images of kdrl:eGFP; gatal:dsRed were taken to observe the vessel development and vascular integrity in psmb6 mutants. The white arrow indicates cerebral hemorrhage. Scale bars: 50 μm. (C) Statistical analysis of midbrain Tg(elavl3:EGFP) fluorescence intensity at 80 hpf by Image J. ∗∗∗∗P < 0.0001, Student's t-test. (D) Hematoxylin and eosin (H&E) staining of transversal sections for 3 dpf psmb6 mutants. Midbrain ventricle (dashed line). OPL, outer plexiform layer (triangle). Scale bars: 100 μm (left panels). Scale bars: 50 μm (middle and right panels). (E) Transmission Electron Microscopy showed dead cells (red arrow) and mitochondrial swelling (pink arrow) in 3 dpf psmb6 mutants. Lower panels show higher magnification images of the yellow boxed areas in upper panels. Outer segments (OS).Scale bars: 5 μm (upper panels), 1 μm (lower panels). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biochem. Biophys. Res. Commun.