FIGURE

Fig. 4

ID

ZDB-FIG-250407-13

Publication

Xu et al., 2025 - The synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger-Huët anomaly and promotes sAML

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Fig. 4

Pelger?Hu�t-like cells are a group of pathological neutrophils with poor differentiation. (A) Five subpopulations of neutrophils (GMP-Gs, GPs, Neutrophils-1, Neutrophils-2, and Neutrophils-3). (B) Temporal analysis of neutrophil in different subtypes (curve arrow indicating differentiation direction). (C) Detailed population diagram of neutrophils composition of wildtype, c-mybhyper, pu.1G242D/G242D, and c-mybhyper;pu.1G242D/G242D. Cells are colored by their cell-type annotation and numbered according to the legend beside. (The blue line indicated Neutrophils-2 population, the yellow line indicated Neutrophils-1 population, and the purple line indicated Neutrophils-3 population.) (D) Enriched GO pathways found in the analysis of DEGs in Neutrophils-3 vs. other neutrophil groups. Gene Ratio means Number of Differentially Expressed Genes/Total Number of Genes in the Pathway. Gene Number means the absolute number of target genes annotated to each pathway. (E) The expression of genes involved in differentiation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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