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Fig. 4 Pelger?Huët-like cells are a group of pathological neutrophils with poor differentiation. (A) Five subpopulations of neutrophils (GMP-Gs, GPs, Neutrophils-1, Neutrophils-2, and Neutrophils-3). (B) Temporal analysis of neutrophil in different subtypes (curve arrow indicating differentiation direction). (C) Detailed population diagram of neutrophils composition of wildtype, c-mybhyper, pu.1G242D/G242D, and c-mybhyper;pu.1G242D/G242D. Cells are colored by their cell-type annotation and numbered according to the legend beside. (The blue line indicated Neutrophils-2 population, the yellow line indicated Neutrophils-1 population, and the purple line indicated Neutrophils-3 population.) (D) Enriched GO pathways found in the analysis of DEGs in Neutrophils-3 vs. other neutrophil groups. Gene Ratio means Number of Differentially Expressed Genes/Total Number of Genes in the Pathway. Gene Number means the absolute number of target genes annotated to each pathway. (E) The expression of genes involved in differentiation.