FIGURE

Fig. 6

ID

ZDB-FIG-250327-71

Publication

Dehner et al., 2025 - Superficial Neurocristic FET::ETS Fusion Tumor: Expanding the Clinicopathological and Molecular Genetic Spectrum of a Recently Described Entity

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Fig. 6

Molecular genetic findings and methylation results. (A) FUS::ETV5 fusion depicted by circos plot, schematic diagram of fusion transcript and predicted chimeric protein with functional domains annotated by National Center for Biotechnology Information RefSeq accession numbers. (B) Uniform Manifold Approximation and Projection (UMAP) plots showing unsupervised clustering of the methylation profiles of all 4 tested tumors in relation to 3 additional superficial neurocristic S100 protein/SOX10-positive tumors, neural tumors, and other mesenchymal neoplasms. Our cases clustered closely with previously reported neurocristic tumors as well as neurofibromas and schwannomas and away from conventional and adamantinoma-like Ewing sarcoma. AFH, angiomatoid fibrous histiocytoma; ALES, adamantinoma-like Ewing sarcoma; ASPS, alveolar soft part sarcoma; CCS, clear cell sarcoma; DFSP, dermatofibrosarcoma protuberan; EMC, extraskeletal myxoid chondrosarcoma; EWS, Ewing sarcoma; ICMT, intracranial mesenchymal tumor; LGFMS, low-grade fibromyxoid sarcoma; MLPS, myxoid liposarcoma; MPNST, malignant peripheral nerve sheath tumor; NFB, neurofibroma; RMS, rhabdomyosarcoma; SCHW, schwannoma; SEF, sclerosing epithelioid fibrosarcoma.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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