FIGURE

Figure 6

ID

ZDB-FIG-250306-38

Publication

Zhang et al., 2025 - Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer

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Figure 6

Effects of IL-6 in vitro stimulation on T cells. (A) Typical graph of reduced GZMB expression in CD8⁺ T cells in the Tumor-B and Tumor groups after 24 h of IL-6 treatment. (B) Frequency graph of reduced IFN-γ expression in CD8⁺ T cells of the Tumor-B and Tumor groups after 24 h of IL-6 treatment. (C) Typical graph of reduced GZMB expression in CD8⁺ T cells of the Tumor-B and Tumor groups after 24 h of IL-6 treatment. (D) Frequency graph of reduced GZMB expression in CD8⁺ T cells of the Tumor-B and Tumor groups after 24 h of IL-6 treatment. (E) Frequency graph of CD8⁺ T cells in the peripheral blood after stimulation with the IL-6 recombinant protein (F) Increased apoptosis of CD3⁺ T cells and CD8⁺ T cells in the peripheral blood after IL-6 treatment for 24 h. Note: Tumor-B and Tumor groups were the peripheral blood PBMC group and the cancer tissue group of patients with non-small cell lung cancer, respectively. ns, not statistically significant. *P < 0.05, **P < 0.01, ***P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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