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Figure 2

ID

ZDB-FIG-250219-33

Publication

Cerveró-Varona et al., 2025 - Amniotic epithelial Cell microvesicles uptake inhibits PBMCs and Jurkat cells activation by inducing mitochondria-dependent apoptosis

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Figure 2

Lipidomic profile of MVs enrichment in lipid mediating signaling and ER/mitochondria is dependent of AEC activation status

(A) Total lipid concentration in AEC ± LPS_tot, AEC± LPS_MV-free, and AEC ± LPS_MV fractions.

(B) Bidimensional principal component analysis (PCA) of all fractions.

(D) Spearman’s rank correlation analysis of the different lipid classes influenced by all CM fractions.

(E and F) Lipid concentration for PE 38:5 and PE 40:5, respectively, in the AEC ± LPS_MV fractions.

(G) Cellular component classification AEC_tot, AEC_{MV- free,} and AEC_MV fractions treated ± LPS assessed with the Lipid Ontology web (LION/web) terms.

(H) Function classification for the “lipid-mediated signaling” term of the lipid ontology web (LION/web). Data (mean ± SD) represent 3 independent sets of experiments (n = at least 3 biological replicates in each group per set; each biological replicate assayed in at least 3 technical replicates). ∗, ∗∗, ∗∗∗, and ∗∗∗∗ Statistically significant values between the different studied groups (p < 0.05, p < 0.01, p < 0.001, and p < 0.0001, respectively). One-way ANOVA and two tailored t-tests were employed for comparing normally distributed data.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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