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Fig. 1

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ZDB-FIG-250217-40

Publication

Zhang et al., 2024 - Using Zebrafish G Protein-Coupled Receptors to Obtain a Better Appreciation of the Impact of Pharmaceuticals in Wastewater to Fish

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Fig. 1

IC50 values of GPCR-acting pharmaceuticals against human (hD2, hβ1, and hH1) and zebrafish (zD2a, zD2c, zβ1, and zH1) receptors. Plots indicate the mean IC50 values (M) of GPCR-acting pharmaceuticals measured in the present study. Red (zD2a, zβ1, and zH1) and blue (zD2c) plots are IC50 values for zebrafish GPCRs, and black plots indicate IC50 values for zebrafish GPCRs (hD2, hβ1, and hH1). Red open circle indicates that the IC50 was >10–5 M; atenolol against zβ1 receptor did not reach 50% AP-TGFα release in the tested concentration range (10–10 to 10–5 M). The IC50 values of GPCR-acting pharmaceuticals against human GPCRs (hD2, hβ1, and hH1) were cited from our previous study. (28)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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